The Neurobiology of NO· and ·OH

This work reflects the current interest in the free radical, nitric oxide, and the hydroxyl radical, which is probably the most reactive oxidant in the human body. The molecular mechanisms underlying neurodegeneration and brain disorders are discussed along with possible future therapeutic strategies for countering these pathologic conditions. The book covers novel transmitter roles, generation and detection of reactive oxygen species in the central nervous system, the role of free radicals in neural transmission, antioxidant defence mechanisms, transgenic animal models, and new chemical antioxidants for protecting brain neurons. This volume should be read by those interested in the ageing of the CNS, Parkinson's disease, Alzheimer's dementia, Down's syndrome, head trauma and stroke.